New generation of medicines targeting G-protein coupled receptors (GPCRs)

Heterotrimeric G protein-coupled receptors (GPCRs) are the largest family of cell surface receptors (1) and play a critical role in transmitting signals from outside to inside a cell.   GPCRs role in cell physiology and pathophysiology is well documented as nearly all physiological functions are dependent on GCPR signaling (1,2).
The activation of a GPCR is a [...]